USDA/CVB Issues Notice on Senecavirus A in Biological Products

SVA lesions are clinically indistinguishable from those caused by exotic agents including foot-and-mouth disease, swine vesicular disease, vesicular stomatitis, and swine vesicular exanthema.
SVA lesions are clinically indistinguishable from those caused by exotic agents including foot-and-mouth disease, swine vesicular disease, vesicular stomatitis, and swine vesicular exanthema.
(Pork magazine)

The USDA’s Center for Veterinary Biologics (CVB) recently issued CVB Notice 18-05 Detection of Senecavirus A (SVA) in Veterinary Biological Products to warn of potential contamination of swine vaccines.

According to CVB, Senecavirus A (SVA) is a single-stranded RNA virus belonging to the family Picornaviridae that causes blister-like lesions on the mouth, snout, and hooves in susceptible swine.

These lesions, they note, are clinically indistinguishable from those caused by exotic agents including foot-and-mouth disease, swine vesicular disease, vesicular stomatitis, and swine vesicular exanthema. This virus was uncommon in the U.S. prior to 2015, but has become more prevalent since then, and is found as a contaminant in porcine trypsin and serum.

The CVB intends its notice to help ensure that veterinary biological product manufacturers who use ingredients of animal origin derived from swine are aware of the issue and can prevent the use of material that does not meet acceptable standards for purity and quality in the manufacturing process.

The CVB is now testing all Master Seeds and Master Cell Stocks that have been produced using ingredients derived from swine for the presence of SVA.

Access the CVB notice for more information.

 

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