The Swine Health Information Center (SHIC) recently funded a study assessing tools for mitigation of Foreign Animal Disease (FAD) and other transboundary pathogens introduction and transmission in feed.
Conducted at Kansas State University, the study will meet the urgent need to understand and define the potential role feed plays in the introduction of diseases like African swine fever virus (ASFV), classical swine fever virus (CSFV), and a Chinese strain of pseudorabies virus (PRV). Each is at the top of the prioritized foreign and endemic pathogens on the SHIC Swine Disease Matrix. CSFV and PRV are endemic to China while ASFV is spreading in eastern Europe.
Reviewed by SHIC’s Monitoring and Analysis Working Group and approved by the organization’s Board of Directors, the study will focus on three key objectives.
Developing baseline laboratory data for the effectiveness of mitigants to inactivate ASFV, CSF, and Chinese PRV. This effort will determine the inactivation rate of each virus when exposed to candidate mitigants.
Testing candidate mitigants using natural feeding exposure in pigs. The approach is to administer the mitigant in a feed formulation and test the effectiveness of inactivating ASFV, CSFV, or Chinese PRV when present in complete feed.
Evaluating the effectiveness of mitigants to neutralize viruses in a model that simulates conditions when feed ingredients are shipped to the U.S. Midwest from another country. This process will evaluate the effectiveness of mitigants if they were added to feed ingredients at the point of origin. In this case, it would be China for PRV and CSFV and eastern Europe for ASFV.
One strength of the project is that a strong research team has been formed to test the mitigants directly on ASFV, CSFV and a strain of PRV now circulating in China. The team incorporates the expertise of virologists, veterinarians, feed scientists, and swine nutritionists from Kansas State University Colleges of Veterinary Medicine and Agriculture, South Dakota State University, and Pipestone Applied Research. The collaboration is also supported by the Biosecurity Research Institute (BRI), a unique high biosecurity facility located on the K-State campus with permits to study these viruses.
This project, expected to be completed within 12 months, is an extension of research going on to evaluate the ability of these viruses to survive in imported feed ingredients under their shipping conditions.