IAV-S in Pigs—Shifting the Approach to Protection

Once considered a seasonal, “simple” virus, influenza A virus in swine (IAV-S) has become an endemic dilemma with detrimental effect on performance and profitability.1,2 Ongoing IAV-S infection is not confined to the nursery; it impacts all phases of a swine operation,2 making it clear that traditional management strategies are no longer as effective or dependable as they once were.

 

Any time there are more than 10 solutions to a problem, probably none of them are very good. And to me, that says a lot about influenza strategy, and what we've done over time and where we are today.

—Mike Eisenmenger, DVM

Swine Vet Center, PA

St. Peter, MN

 

Traditional IAV-S management strategies, focused on sow vaccination, may be useful when implemented only to protect sow herds from the reproductive repercussions of a new IAV-S introduction.3–5 But prefarrowing sow vaccination to protect piglets against IAV-S in the nursery depends on the transfer of maternal antibodies (mAb) in colostrum from the vaccinated sow,3-5 which has several limitations. These limitations—the need for homology between mAb and challenge viruses, a lack of uniform antibody concentrations delivered to piglets, mAb interference, and the decline of mAb concentrations as pigs grow—have led to continued frustration as IAV-S remains an ongoing health issue in the swine population.3-5 When piglets are unable to develop their own immunity, they remain vulnerable and unprotected against IAV-S.6

 

Individual pigs need individual protection—from start to finish

 

In IAV-S-endemic sow herds, newborn pigs can become infected with IAV-S through exposure to continuously circulating virus in the farrowing house. Although they may be mildly infected or subclinical at that time, once weaned, pigs infected with IAV-S are at risk for increased morbidity and mortality7,8 and transmit IAV-S to more pigs when they are commingled in a larger population.9,10

 

Additionally, an increased burden of respiratory pathogens leads to increased numbers of clinically affected pigs. Respiratory disease in pigs causes lost productivity by compromising growth and performance. This reduced performance has a direct economic impact on producers.11,12

 

Adequate IAV-S control strategies must get ahead of these IAV-S challenges. Early vaccination, before exposure, allows a pig to mount a strong natural immunity.

 

If we have an available vaccine that is cross-protective and can be used in young pigs, I’d say it has the opportunity to be widely used and over time then decrease the prevalence of influenza that’s circulating in our sow populations and our suckling pig populations.

— Joseph F. Connor, DVM, MS

President and Founder, Carthage Veterinary Service

Carthage, IL

 

Ingelvac Provenza™ for swine protection

 

Ingelvac Provenza™ is an intranasally administered, bivalent live attenuated influenza vaccine (LAIV) that offers broad protection against IAV-S. Ingelvac Provenza has been shown to be effective for the vaccination of healthy pigs 1 day of age or older, demonstrating cross-protection against relevant circulating IAV-S strains and a reduction in viral shedding.

 

Additionally, intranasal administration stimulates mucosal immunity where it is needed most —at the natural site of infection.3,4 One study evaluating LAIV protection in the face of mAb showed a significant decrease in the detection and duration of shedding viable virus.13

 

Reducing the amount of influenza virus shed by infected pigs reduces IAV-S transmission among and between animals at a given site. This reduced transmission decreases the impact of influenza in a swine operation and can help producers achieve unrealized pig health and performance.

 

Shifting the approach to piglet protection through direct piglet vaccination provides more complete and uniform immunity against IAV-S, compared to maternally derived immunity, with the added benefit of administration as early as day 1. An LAIV works to protect pigs throughout all growing phases.

 

With Ingelvac ProvenzaTM, you can now protect pigs before they leave the sow farm.

 

For more information on how Ingelvac Provenza™ offers a new approach in the management of IAV-S for swine protection as early as day 1, visit IngelvacProvenza.com.

 

 

 

References: 1. Diaz A, Perez A, Sreevatsan S, Davies P, Culhane M, Torremorell M. Association between influenza A virus infection and pigs subpopulations in endemically infected breeding herds. PLoS One. 2015;10(6):e0129213. doi:10.1371/journal.pone.0129213. 2. Vincent AL, Perez DR, Rajao D, et al. Influenza A virus vaccines for swine [published online ahead of print November 24, 2016]. Vet Microbiol. 2016;206:35–44. doi:10.1016/j.vetmic.2016.11.026. 3. Vincent AL, Ma W, Lager KM, et al. Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine. Vaccine. 2007;25:7999–8009 4. Janke BH. Influenza A virus infections in swine: pathogenesis and diagnosis. Vet Pathol. 2014;51(2):410–426. 5. Vincent AL, Lager KM, Janke BH, Gramer MR, Richt JA. Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine. Vet Microb. 2008;126:310–323. 6. Loeffen WLA, Heinen PP, Bianchi ATJ, et al. Effect of maternally derived antibodies on the clinical signs and immune response in pigs after primary and secondary infection with an influenza H1N1 virus. Vet Immunol Immunopath. 2003;92:23–35. 7. Alvarez J, Sarradell J, Kerkaert B, et al. Association of the presence of influenza A virus and porcine reproductive and respiratory syndrome virus in sow farms with post-weaning mortality. Prev Vet Med. 2015;121:240–245. 8. Vincent AL, Lager KM, Anderson TK. A brief introduction to influenza A virus in swine. In: Spackman E, ed. Methods in Molecular Biology: Animal Influenza Virus, Part III. 2014;1161:243–258. 9. Pitzer VE, Aguas R, Riley S, Loeffen WLA, Wood JLN, Grenfell BT. High turnover drives prolonged persistence of influenza in managed pig herds. J R Soc Interface. 2016;13:20160138. doi:10.1098/rsif.2016.0138. 10. Allerson MW, Davies PR, Gramer MR, Torremorell M. Infection dynamics of pandemic 2009 H1N1 influenza virus in a two-site swine herd. Transbound Emerg Dis. 2014;61:490–499. 11. Dykhuis Haden C, Painter T, Fangman T, Holtkamp D. Assessing production parameters and economic impact of swine in influenza, PRRS and Mycoplasma hyopeumoniae on finishing pigs in large production system. In: Proceedings of the 43rd American Association of Swine Veterinarians Annual Meeting: March 10–13, 2012; Denver, CO: 75–76. 12. Stika R, Holtkamp D, Goodell C, et al. Assessment of the association between respiratory pathogen burden and the productivity of growing pigs. In: Proceedings of the 49th American Association of Swine Veterinarians Annual Meeting: March 3–6, 2018; San Diego, CA: Poster 10. 13. Genzow M, Goodell C, Kaiser TJ, Johnson W, Eichmeyer M. Live attenuated influenza virus vaccine reduces virus shedding of newborn piglets in the presence of maternal antibody. Influenza Other Respir Viruses. 2017;00:1–7. doi:10.1111/irv.12531.
 
Ingelvac Provenza is a trademark of Boehringer Ingelheim Vetmedica GmbH.
© 2018 Boehringer Ingelheim Vetmedica, Inc.  POR-0990-PRO0618    18234
 
 

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